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	<title>BMI &#187; india</title>
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	<description>Bariatrics &#38; Metabolism Initiative</description>
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		<title>GASTRIC PLICATION: A NEW WLS PROCEDURE!</title>
		<link>http://www.bmi-india.com/gastric-plication-a-new-wls-procedure/</link>
		<comments>http://www.bmi-india.com/gastric-plication-a-new-wls-procedure/#comments</comments>
		<pubDate>Sun, 18 Jul 2010 04:22:12 +0000</pubDate>
		<dc:creator>ramana</dc:creator>
				<category><![CDATA[Complications]]></category>
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		<category><![CDATA[Obesity Research]]></category>
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		<category><![CDATA[Sleeve Gastrectomy]]></category>

		<guid isPermaLink="false">http://www.bmi-india.com/?p=456</guid>
		<description><![CDATA[Many bariatric surgeons are excited about the procedure Gastric Plication (LGP) as a bariatric procedure. It promises to be a simple method (remember, &#8220;Less Is More!&#8221;) that gives weight loss results as good as sleeve gastrectomy without even the risks of that procedure (staple line leaks (read part one and part two here) or bleeding). [...]]]></description>
			<content:encoded><![CDATA[<p>Many bariatric surgeons are excited about the procedure <em><strong><span style="color: #ff0000;">Gastric Plication</span></strong></em> (LGP) as a bariatric procedure. It promises to be a simple method (remember, <span style="color: #ff0000;"><em>&#8220;Less Is More!&#8221;</em></span>) that gives weight loss results as good as sleeve gastrectomy without even the risks of that procedure (staple line leaks (read <a href="http://www.bmi-india.com/leaks-after-sleeve-gastrectomy-part-one/">part one</a> and <a href="http://www.bmi-india.com/leaks-after-sleeve-gastrectomy-part-two/">part two</a> here) or bleeding).</p>
<p>What is done is that the greater curvature of the stomach is freed from the tissues attached to it (known as the gastrocolic omentum) using a vessel sealing device like the Harmonic Scalpel or the Ligasure. This is the first step of the sleeve gastrectomy procedure, as well.</p>
<p>However, unlike the sleeve, here we do not use the stapler to remove 80% of the stomach. We merely imbricate/plicate the stomach using running stitches from above downwards, layer by layer, till most of the stomach is pushed inwards, creating a narrowing of the passage, and a tunnel along the lesser curvature, just like the sleeve.</p>
<p><object classid="clsid:d27cdb6e-ae6d-11cf-96b8-444553540000" width="425" height="350" codebase="http://download.macromedia.com/pub/shockwave/cabs/flash/swflash.cab#version=6,0,40,0"><param name="src" value="http://www.youtube.com/v/ZebH8ad_KAc" /><embed type="application/x-shockwave-flash" width="425" height="350" src="http://www.youtube.com/v/ZebH8ad_KAc"></embed></object></p>
<p>Lap Gastric Plication</p>
<p>In the same vein, if someone wants to reverse the procedure, the stitches may be removed by laparoscopy (making this a potentially reversible procedure like the Lap Band), though this would neither be a good thing nor a great experience!</p>
<p>Some patients have significant reflux symptoms after LGP, as after the sleeve, as we have <a href="http://www.bmi-india.com/?s=acid+reflux">discussed before</a>.</p>
<p>It is possible that the stitches may give way later and hamper the weight loss, but preliminary results, as presented in the recent International Conference of Obesity in Stockholm, show good results akin to the sleeve.</p>
<p>More info later!</p>

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		<title>WEIGHT LOSS PLATEAU AFTER SLEEVE GASTRECTOMY: WHAT NOW?</title>
		<link>http://www.bmi-india.com/weight-loss-plateau-after-sleeve-gastrectomy-what-now/</link>
		<comments>http://www.bmi-india.com/weight-loss-plateau-after-sleeve-gastrectomy-what-now/#comments</comments>
		<pubDate>Wed, 30 Jun 2010 16:09:41 +0000</pubDate>
		<dc:creator>ramana</dc:creator>
				<category><![CDATA[Complications]]></category>
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		<category><![CDATA[Obesity Research]]></category>
		<category><![CDATA[Practice]]></category>
		<category><![CDATA[Sleeve Gastrectomy]]></category>
		<category><![CDATA[Uncategorized]]></category>
		<category><![CDATA[bariatric surgery]]></category>
		<category><![CDATA[blog]]></category>
		<category><![CDATA[fat loss]]></category>
		<category><![CDATA[india]]></category>
		<category><![CDATA[obesity]]></category>
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		<category><![CDATA[weight loss failure]]></category>

		<guid isPermaLink="false">http://www.bmi-india.com/?p=393</guid>
		<description><![CDATA[Weight loss plateaus may occur in certain patients who have undergone a sleeve gastrectomy as a primary bariatric procedure. What are the causes? What is the next step? What is the prognosis for these patients? This article discusses these issues. Please buckle your seat belts! First things first, who doesn&#8217;t know what a sleeve (as [...]]]></description>
			<content:encoded><![CDATA[<p><strong> Weight loss plateaus</strong> may occur in certain patients who have undergone a sleeve gastrectomy as a primary bariatric procedure. <em><strong>What are the causes? What is the next step?<br />
What is the prognosis for these patients?</strong></em></p>
<p>This article discusses these issues. Please buckle your seat belts!</p>
<p>First things first, who doesn&#8217;t know what a sleeve (as this operation will from now on be called) is and what it is for? Please refer to our Procedures page and also search this site for many other articles on this popular weight loss procedure.</p>
<p>Normally, the <strong>weight loss expected</strong> out of the sleeve is in the whereabouts of <strong>50-80 percent</strong> of excess body weight. This is usually achieved in the vicinity of <strong>one year</strong> and may go on till <strong>three years</strong>, after which time there is usually no inherent weight loss from the surgery. This does not mean you will stop losing weight after that time. You could lose weight if your diet and exercise plans are on the spot. But in practice, weight loss plateaus in and around the third year. A <a href="http://www.soard.org/article/S1550-7289(09)00530-9/abstract">recent study</a> from India published in the journal SOARD reports a nearly <strong>75 percent weight loss</strong> of the sleeve in three years.</p>
<p><img class="alignnone size-medium wp-image-415" title="Screen shot 2010-06-30 at 9.17.19 PM" src="http://www.bmi-india.com/wp-content/uploads/2010/06/Screen-shot-2010-06-30-at-9.17.19-PM1-300x261.png" alt="" width="300" height="261" /></p>
<p><em><span style="color: #ff0000;">(the stomach being stapled at BMI, Kolkata. Procedure done at Belle Vue Clinic)</span></em></p>
<p>So, the weight loss curve hits a plateau at a point in time. In itself, this is a benefit, as sleeve patients would shrink to oblivion otherwise! So, now that the weight loss plateau is upon you, what to do?</p>
<p><img class="alignnone size-medium wp-image-416" title="Screen shot 2010-06-30 at 9.18.45 PM" src="http://www.bmi-india.com/wp-content/uploads/2010/06/Screen-shot-2010-06-30-at-9.18.45-PM1-300x263.png" alt="" width="300" height="263" /></p>
<p><em><span style="color: #ff0000;">(the stapling process proceeds towards the direction of the foodpipe/esophagus)</span></em></p>
<p>Before we answer this, let us eliminate one important cause of<strong> weight regain*</strong> after the sleeve: a <strong>residual fundus</strong>. This means that the upper baggy part of the stomach, which is the source of the hunger hormone ghrelin, has not been fully removed by the surgery (usually a technical error). If this is detected, it is bad news.</p>
<p>*<span style="color: #ff0000;"><em><strong>The definition of this is taken to be a weight regain of 10 kgs from the nadir (bottom) of the weight loss curve.</strong></em></span></p>
<p><img class="alignnone size-medium wp-image-414" title="Screen shot 2010-06-30 at 9.24.42 PM" src="http://www.bmi-india.com/wp-content/uploads/2010/06/Screen-shot-2010-06-30-at-9.24.42-PM1-296x300.png" alt="" width="296" height="300" /></p>
<p><em><span style="color: #ff0000;">(the resected stomach being removed through one of the port sites)</span></em></p>
<p>In order to get the desired weight loss, <strong>re-surgery </strong>has to be undertaken. In such a case, we do one of the following:</p>
<p><strong>1</strong>. <strong>Re-sleeve</strong>: using an endoscopic stapler, the extra fundus (the culprit) is excised. An option to create a narrower sleeve is also possible, but would mean more staplers, and higher cost.</p>
<p><strong>2</strong>. <strong>Convert to a Roux-en-Y gastric bypass</strong>: especially if the patient is super-super-obese (BMI more than 60), where the sleeve is usually the first of a two-stage operative strategy. An alternative we can explore in the Western/Muslim/non-vegetarian super-super-obese patient is the <strong>Duodenal Switch</strong> (DS). The reason for this is that these patient classes usually eat enough proteins by way of meats. This is a very crucial consideration as the DS causes severe malabsorption of proteins and fats and can cause debilitating malnutrition in the vegetarian patient.</p>
<p><strong>3</strong>. <strong>A </strong><a href="http://www.ncbi.nlm.nih.gov/pubmed/20467914"><strong>banded sleeve</strong></a>. This adds an additional restrictive element to the sleeve, but has the disadvantages that a Lap Band normally carries (which is another full article). In short, high explantation rates, erosions, prolapse of gastric mucosa, esophageal dilatation, etc.</p>
<p>In a special section on sleeve gastrectomy published June 2010 in the journal Surgical Laparoscopy, Endoscopy &amp; Percutaneous Techniques, I quote:</p>
<blockquote><p>Similar to the banded gastric bypass, a band can also be placed in SG performed as ‘‘<strong>primary banded sleeve gastrectomy</strong>,’’ as published by Alexander et al. In this series of 27 patients, a band of 6 cm length made of biologic tissue (AlloDerm) was placed approximately	6 cm	below	the	gastro-esophageal	junction.</p></blockquote>
<p>This is same, but different, compared to the former &#8220;<strong>secondary</strong>&#8221; sleeve banding described by Greenstein.</p>
<p>In some cases, <strong>improper eating</strong> (large feeds, drinking colas and binge eating) can cause the gastric tube (sleeve) to become dilated. Though the initial surgery may have been perfect, the end result is similar to that of a residual fundus after primary surgery: inadequate weight loss, or an early weight loss plateau. This is the reason it is critical to screen patients before surgery for eating disorders and psychiatric conditions that make for unreliable post-op compliance (which means we don&#8217;t want to operate on patients who won&#8217;t listen to us, and are likely to screw up the results of surgery and give us a bad name).</p>
<p>Let&#8217;s get back to the originally asked question. If you underwent a gastric sleeve surgery, and there were no operation-related problems and you lost 70-75% of your excess body weight in, say, three and a half years, BUT you put back 5 kgs in the last few months, what to do?</p>
<p>First, we evaluate the stomach: is it dilated? Is there a residual fundus?</p>
<p>If there is no surgically significant problem, we must get back to basics.</p>
<p>Our <strong>strategy</strong> is simple:</p>
<p>1. <strong><span style="color: #0000ff;">Motivation</span></strong>: talk, talk and more talk. Help the patient understand how results should be the focus, not eating.</p>
<p>2. <strong><span style="color: #0000ff;">Eliminate</span></strong> processed foods, sugars, sweetened beverages, alcohol, and other such temptations.</p>
<p>3. Reserve <strong><span style="color: #0000ff;">grains</span></strong> as a cheat meal, not as a daily component of the diet.</p>
<p>4. Put some patients on a <strong><span style="color: #0000ff;">low-carb</span></strong> diet.</p>
<p>5. Careful <strong><span style="color: #0000ff;">food journaling</span></strong> and monitoring of nutritional intake. An online journal may be kept for free at www.fitday.com (or similar sites).</p>
<p>6. <strong><span style="color: #0000ff;">Fish oil </span></strong>capsule supplements: 1.8 to 3 grams daily (around 6-8 caps daily).</p>
<p>7. <strong><span style="color: #0000ff;">Activity</span></strong> guidance: walk, cycle, play, climb, skip. Don&#8217;t sit, slouch, drive, ride.</p>
<p>8.  <strong><span style="color: #0000ff;">Exercise</span></strong>: strength training with cardio, both HIIT and long-slow cardio.</p>
<p>Once we hit the system with renewed vigor, you will soon be back on track with weight loss!</p>
<p><em>References</em>:</p>
<p>1. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18074485?dopt=Abstract">Revisional bariatric surgery for inadequate weight loss.</a> Gumbs AA, Pomp A, Gagner M. Obesity Surgery, Sept 2007.</p>
<p>2. <a href="http://www.ncbi.nlm.nih.gov/pubmed/17132421?dopt=Abstract">Re-sleeve gastrectomy</a>. Baltasar, et al. Obesity Surgery, Nov 2006.</p>
<p>3. <a href="http://www.ncbi.nlm.nih.gov/pubmed/19572113?dopt=Abstract">The Spanish study on sleeve gastrectomy outcomes</a>. Obesity Surgery, Sept 2009.</p>
<p>4.<a href="http://www.ncbi.nlm.nih.gov/pubmed/18317859?dopt=Abstract"> French prospective multicenter study: results at 1 and 2 years</a>. Nocca, et al. Obesity Surgery May 2008.</p>
<p>5. <a href="http://www.ncbi.nlm.nih.gov/pubmed/18704605?dopt=Abstract">LSG with minimal morbidity</a>. Rubin, et al. Obesity Surgery Dec 2008.</p>
<p>6. Greenstein&#8217;s <a href="http://www.ncbi.nlm.nih.gov/pubmed/18586565">article link</a> in SOARD.</p>
<p>7. <a href="http://www.springerlink.com/content/964ujtn159786412/">Banded Sleeve Gastrectomy</a>. Alexander et al. Obesity Surgery, Sept 2009.</p>

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		<title>FOCUS</title>
		<link>http://www.bmi-india.com/focus/</link>
		<comments>http://www.bmi-india.com/focus/#comments</comments>
		<pubDate>Sat, 08 May 2010 12:31:05 +0000</pubDate>
		<dc:creator>ramana</dc:creator>
				<category><![CDATA[Diet]]></category>
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		<guid isPermaLink="false">http://www.bmi-india.com/?p=345</guid>
		<description><![CDATA[Some of the commonest things I get asked by patients after bariatric surgery is, &#8220;So what can I eat now? When can I eat sweets? When can I drink Coke?&#8221; Or words to that effect. Each time, I sigh. It means another ten minute lecture is due on my part. I have to teach an [...]]]></description>
			<content:encoded><![CDATA[<p>Some of the commonest things I get asked by patients after bariatric surgery is, &#8220;So what can I eat now? When can I eat sweets? When can I drink Coke?&#8221; Or words to that effect.</p>
<p>Each time, I sigh. It means another ten minute lecture is due on my part. I have to teach an important lesson to the patient (not to mention the family) all over again.</p>
<p><img style="-webkit-user-select: none;" src="http://www.ineedtostopsoon.com/wp-content/uploads/2006/06/Mire-back-focus.gif" alt="" /></p>
<p>So my lecture goes somewhat like this:</p>
<blockquote><p><em><strong>Why are you here? Because eating the way you do has led to a level of obesity that is dangerous to your health and even your very existence. You have suffered endlessly because of your obesity. You have lived through your own self-recrimination, the admonishment of your family, the chiding and teasing of your friends, and countless other miseries unique to the severely obese individual.</strong></em></p>
<p><em><strong>Eating the kind of foods the way you have been eating has caused you so many life-threatening diseases like diabetes, sleep apnea and hypertension. Eating sugars and junk has brought you to surgery as a last resort.</strong></em></p>
<p><em><strong>So why are you not looking further ahead to being leaner and healthier? Why are you looking back to eating the same kind of way that has made you what you are today? Look at this thing in perspective. You have a whole new life ahead. Plan on how you can make the most of this with your new-found health and look. Liberate yourself from guilt and misery. Focus! The goal is health and leanness, not food. Focus! Look, you are several trouser sizes down! Look, you look great in that new slim-fit T-shirt! Look, people are wide-eyed at your transformation. Look, your husband thinks you are beautiful again!</strong></em></p>
<p><em><strong>Don&#8217;t miss these achievements. None of this is possible if you think surgery is your destination. It is not. Surgery is your vehicle. It will take you where you would never have dreamed of reaching. But you will do so only if you keep sight of your goals. That is what is called FOCUS.</strong></em></p></blockquote>

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		<title>DIET AFTER A SLEEVE GASTRECTOMY&#8211;PART ONE</title>
		<link>http://www.bmi-india.com/diet-after-a-sleeve-gastrectomy-part-one/</link>
		<comments>http://www.bmi-india.com/diet-after-a-sleeve-gastrectomy-part-one/#comments</comments>
		<pubDate>Fri, 18 Sep 2009 14:47:51 +0000</pubDate>
		<dc:creator>ramana</dc:creator>
				<category><![CDATA[Diet]]></category>
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		<guid isPermaLink="false">http://www.bmi-india.com/?p=231</guid>
		<description><![CDATA[The sleeve gastrectomy operation converts the stomach into a long tube with a capacity of around 120 ml (or whereabouts). Obviously, you cannot exceed the newly reduced capacity, and your meals are going to be small, though much bigger than after a gastric bypass.  To make matters better (and more interesting) you do not feel [...]]]></description>
			<content:encoded><![CDATA[<p><span style="text-align:justify;"><br />
The sleeve gastrectomy operation converts the stomach into a long tube with a capacity of around 120 ml (or whereabouts). Obviously, you cannot exceed the newly reduced capacity, and your meals are going to be small, though much bigger than after a gastric bypass. </p>
<p>To make matters better (and more interesting) you do not feel too hungry anyways, and there are usually no cravings for food that go unfulfilled. It is not as if the operation will leave you salivating for a huge meal, and you are cursed with a tiny portion of it all your life. You will be happy with what (and how much) you <em>can</em> eat.<span id="more-231"></span></p>
<p><strong><em>For three to four weeks after surgery, you will consume liquids only.</em></strong> </p>
<p><strong><span style="color: #0000ff;">Week One</span>:</strong> <em><span style="color: #0000ff;">Thin liquids only</span></em></p>
<blockquote>
<div><span style="font-family: 'Times New Roman'; line-height: normal;"><strong><strong>Sample Full Liquid Meal Plan (1 week post-op) </strong> </p>
<p>  7:00  am &#8212; 4 ounces of milk</p>
<p>8:00   am &#8212;  2 Tablespoons plain yogurt  </p>
<p>10:00  am &#8212; 1 ounce whey protein isolate drink (e.g. Isopure Zero Carb) with 4 ounces  </p>
<p>  of skim or 1% milk </p>
<p>11:00 am &#8212; cup of dal</p>
<p>1:00 pm &#8212; 2 Tablespoons low fat cottage cheese (plain) </p>
<p>3:00 pm &#8212; 4 ounces whey protein isolate drink  </p>
<p>6:00 pm &#8212;  tea</p>
<p>8:00 pm &#8212; 4 ounces whey protein isolate drink made with skim or 1% milk </p>
<p>9:00  pm &#8212; 4 ounces of  vegetable/chicken soup  </p>
<p> </p>
<p><strong><span style="color: #0000ff;">Week Two to Week Four</span>:</strong> <em><span style="color: #0000ff;">Pureed/blenderized diet</span></em></p>
<p>Use natural, whole foods (like vegetables, meats, fish, dal and milk) and blenderize them till you obtain the consistency of a thick sauce. Strain out the larger particles/seeds/skin and use the rest. </p>
<p>How to measure your portions: use a measuring spoon or shot glass or an ice tray (each cube in the tray measures 1 ounce.</p>
<p></strong> </p>
<p></span></div>
<div><span style="color: #0000ee; font-family: 'Times New Roman'; line-height: normal; text-decoration: underline;"><br />
</span></div>
</blockquote>
<div>Useful link for pureed diet recipes: <a href="http://www.muschealth.com/weightlosssurgery/nutrition/RecipesPureed">click here</a>. But remember to follow the <strong>rules</strong>!</div>
<div></div>
<div><span style="line-height: normal;"><span style="color: #0000ff;"><strong>Rules for the liquid/pureed diet after operation:<span style="color: #000000; font-weight: normal; line-height: 19px;"><img class="alignnone size-medium wp-image-234" title="_chocolate-shake_drink-__959547" src="http://www.bmi-india.com/wp-content/uploads/2009/09/chocolate-shake_drink-__959547-256x300.jpg" alt="_chocolate-shake_drink-__959547" width="256" height="300" /></span></strong></span></span></div>
<div><span style="line-height: normal;"><span style="color: #0000ff;"><strong><span style="color: #000000; font-weight: normal; line-height: 19px;">(pic source: <a href="http://www.focus28wellness.com/focus28-blog/category/bariatrix-rx/">here</a>)</span></strong></span></span></div>
<blockquote>
<div><strong>1. No colas, sodas, or alcohol.</strong></div>
<div><strong>2. No sugar, commercial &#8216;low-fat&#8217; drink, honey, agave nectar, corn syrup or HFCS, chocolate syrup, ice cream, etc. Your protein shake (as in the pic) may be chocolate-flavored.</strong></div>
<div><strong>3. Very limited ghee, butter, or olive oil.</strong></div>
<div><strong>4. Avoid coffee, especially if you have heart problems or diabetes.</strong></div>
<div><strong>5. Avoid restaurant food (they generally tend to be unhealthy).</strong></div>
<div><strong>6. Avoid hard meats and nuts till well into your second month after surgery.</strong></div>
<div><strong>7. If you feel like having something sweet (like milk or tea or a smoothie), add a sugar substitute, avoiding overuse.</strong></div>
<div><strong>8. No processed foods like chips, cakes, cookies, breads, pizzas, burgers, whatever!</strong></div>
<div><strong>9. Total fluid consumption in a day should be at least 1.5 to 2 litres (including water)</strong></div>
<div><strong>10. Take time in having your meals- your stomach is not what it used to be!</strong></div>
<div><strong>11. Have only less than 4 ounces of feeds at a time. </strong></div>
<div><strong>12. Eat 60 to 100 grams of proteins daily. </strong></div>
<div><strong>13. Use an online food journal like Fitday to calculate your protein intake or contact us.</strong></div>
<div><strong>14. Drink water at a different time from your meal.</strong></div>
<div><strong>15. Avoid fruit juices&#8211; they have a high glycemic index and could raise your blood glucose. </strong></div>
<div><strong><a href="http://www.bmi-india.com/wp-content/uploads/2009/09/bariatric-diet.gif"><img class="alignnone size-full wp-image-237" title="bariatric-diet" src="http://www.bmi-india.com/wp-content/uploads/2009/09/bariatric-diet.gif" alt="bariatric-diet" width="200" height="234" /></a></strong></div>
<div><strong>(pic source: <a href="http://www.bariatric.us/bariatric-surgery-diet.html">here</a></strong><strong>)</strong></div>
<div><strong>In regard to the above, weight training is as important, but that is another article!</strong></div>
<div><strong><br />
</strong></div>
</blockquote>
<div><span style="font-family: 'Times New Roman'; line-height: normal;"><br />
</span></div>
<p></span></p>

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		<title>BMI AND MORTALITY RATES IN RURAL INDIA</title>
		<link>http://www.bmi-india.com/bmi-and-mortality-rates-in-rural-india/</link>
		<comments>http://www.bmi-india.com/bmi-and-mortality-rates-in-rural-india/#comments</comments>
		<pubDate>Sat, 15 Aug 2009 03:28:36 +0000</pubDate>
		<dc:creator>ramana</dc:creator>
				<category><![CDATA[Diet]]></category>
		<category><![CDATA[Featured]]></category>
		<category><![CDATA[Obesity Research]]></category>
		<category><![CDATA[india]]></category>
		<category><![CDATA[nutrition]]></category>
		<category><![CDATA[malnutition]]></category>

		<guid isPermaLink="false">http://www.bmi-india.com/?p=180</guid>
		<description><![CDATA[Abstract of original article is here. The study compares over 75,000 rural people and follows them up over ten years. The study has the interesting finding that the lower the BMI, the higher the mortality. This underscores once again that the problems of rural India are different from those of urban India. A similar study [...]]]></description>
			<content:encoded><![CDATA[<p><span style="text-align:justify;"><br />
Abstract of original article is <a href="http://ije.oxfordjournals.org/cgi/content/abstract/37/5/990"><strong>here</strong></a>.</p>
<p>The study compares over 75,000 rural people and follows them up over ten years. The study has the interesting finding that the lower the BMI, the higher the mortality. This underscores once again that the problems of rural India are different from those of urban India. A similar study based on our city-based population could throw up interesting results.<span id="more-180"></span></p>
<p>From the abstract:</p>
<blockquote><p><strong><em><span style="color: #0000ff;">Background</span></em></strong><em><span style="color: #0000ff;"> Although the detrimental effect of overweight and</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">obesity has been extensively reported in Western populations,</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">little is known on the association between body weight, weight</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">change and mortality in Asian populations whose weight distribution</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">and mortality differ considerably from the West.</span></em></p>
<p><strong><em><span style="color: #0000ff;">Methods</span></em></strong><em><span style="color: #0000ff;"> A cohort of 75 868 subjects aged 35 years and above,</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">participants of the Trivandrum Oral Cancer Study—a cluster-randomized</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">controlled trial originally implemented to evaluate the efficacy</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">of visual inspection on oral cancer, in Kerala State, South</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">India—were followed up from 1995 to 2004. Weight and height</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">were measured both at baseline and in 3.5-year follow-up surveys.</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">Early years of follow-up were excluded from the analyses. Relative</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">risks of overall death and cause-specific death were estimated</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">according to the body mass index (BMI) category of the WHO Asian</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">population definitions, and to weight changes between two surveys.</span></em></p>
<p><strong><em><span style="color: #0000ff;">Results</span></em></strong><em><span style="color: #0000ff;"> Low BMI was a predictor of mortality, while high BMI</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">was not. Mortality risks in men adjusted for age, smoking habits</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">and other potential confounders, as compared with a BMI 18.5–22.9</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">kg/m</span></em><sup><em><span style="color: #0000ff;">2</span></em></sup><em><span style="color: #0000ff;">, were 1.26 (95% CI 1.03–1.55) for BMI &lt; 16 kg/m</span></em><sup><em><span style="color: #0000ff;">2</span></em></sup><em><span style="color: #0000ff;">;</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">1.16 (1.03–1.32) for BMI = 16–18.4 kg/m</span></em><sup><em><span style="color: #0000ff;">2</span></em></sup><em><span style="color: #0000ff;">; 0.95 (0.81–1.12)</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">for BMI = 23–24.9 kg/m</span></em><sup><em><span style="color: #0000ff;">2</span></em></sup><em><span style="color: #0000ff;">; 0.85 (0.69–1.05) for BMI</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">= 25–27.4 kg/m</span></em><sup><em><span style="color: #0000ff;">2</span></em></sup><em><span style="color: #0000ff;">; and 0.89 (0.65–1.21) for BMI  27.5</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">kg/m</span></em><sup><em><span style="color: #0000ff;">2</span></em></sup><em><span style="color: #0000ff;">. Similar findings were observed in women. BMI was not</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">associated with deaths from cancer, cardiovascular and cerebrovascular</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">diseases, and diabetes. A low BMI (&lt;16 kg/m</span></em><sup><em><span style="color: #0000ff;">2</span></em></sup><em><span style="color: #0000ff;">) was associated</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">with increased deaths from chronic respiratory diseases. Smoking</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">and socio-economical status did modify the association. A moderate</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">weight gain of 4–10% between the two surveys was associated</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">with decreased risk of death, while moderate and severe weight</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">loss were predictive factors of death. Similar results were</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">observed in both men and women.</span></em></p>
<p><strong><em><span style="color: #0000ff;">Conclusions</span></em></strong><em><span style="color: #0000ff;"> Among this Indian rural population, mild to severe</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">leanness (BMI &lt; 16 kg/m</span></em><sup><em><span style="color: #0000ff;">2</span></em></sup><em><span style="color: #0000ff;">) and weight loss were important</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">determinants of mortality, especially from chronic respiratory</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">diseases, while overweight and above (BMI &gt; 23 kg/m</span></em><sup><em><span style="color: #0000ff;">2</span></em></sup><em><span style="color: #0000ff;">) did</span></em><sup><em><span style="color: #0000ff;"> </span></em></sup><em><span style="color: #0000ff;">not show any detrimental effect.</span></em></p></blockquote>
<p></span></p>

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