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	<title>BMI &#187; drugs for obesity</title>
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	<description>Bariatrics &#38; Metabolism Initiative</description>
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		<title>PERSPECTIVE</title>
		<link>http://www.bmi-india.com/perspective/</link>
		<comments>http://www.bmi-india.com/perspective/#comments</comments>
		<pubDate>Wed, 26 May 2010 04:34:09 +0000</pubDate>
		<dc:creator>ramana</dc:creator>
				<category><![CDATA[Diet]]></category>
		<category><![CDATA[Exercise]]></category>
		<category><![CDATA[Featured]]></category>
		<category><![CDATA[Practice]]></category>
		<category><![CDATA[Psychology]]></category>
		<category><![CDATA[bariatric surgery]]></category>
		<category><![CDATA[blog]]></category>
		<category><![CDATA[fat loss]]></category>
		<category><![CDATA[metabolism]]></category>
		<category><![CDATA[diabetes]]></category>
		<category><![CDATA[drugs for obesity]]></category>
		<category><![CDATA[IF]]></category>
		<category><![CDATA[obesity]]></category>
		<category><![CDATA[weight training]]></category>

		<guid isPermaLink="false">http://www.bmi-india.com/?p=390</guid>
		<description><![CDATA[&#8220;When you have a hammer, everything looks like a nail!&#8221; We have all heard of this saying, and all of us agree. A skilled laparoscopic surgeon plots to take out huge tumors and cysts through the keyhole method, while the dinosaur surgeon tends to think of employing his hands to remove organs (like the appendix) [...]]]></description>
			<content:encoded><![CDATA[<p><em><strong>&#8220;When you have a hammer, everything looks like a nail!&#8221;</strong></em></p>
<p>We have all heard of this saying, and all of us agree. A skilled laparoscopic surgeon plots to<strong><span style="color: #ff0000;"> </span></strong><a href="http://www.youtube.com/watch?v=5AFGSxNi_RM"><strong><span style="color: #ff0000;">take out huge tumors</span></strong></a> and cysts through the keyhole method, while the dinosaur surgeon tends to think of employing his hands to remove organs (like the appendix) that may have been better left alone.</p>
<p>Let me tell you a small story about myself. Not too long ago, at a Bariatric Surgery conference three or some years back, I had a chat with a renowned endocrinologist who was known for his work in obesity and diabetes. At that time, I was 86 kgs heavy, and most of it was fat. A hard-working surgeon, I was in the peak of physical <em>un</em>-fitness and a heart attack waiting to happen. My resting heart rate was always around 100 and my blood glucose was similarly poised over the century mark. I asked this gentleman how I could improve my markers and lose my fat. I also didn&#8217;t want to become a diabetic, I said.</p>
<p>He told me what anyone in his position would have: take a <a href="http://en.wikipedia.org/wiki/Metformin">metformin</a> pill, and do some walking. If your sugar levels go up, we will add another drug, he said.</p>
<p>I thought long and hard over what he said. I embarked on a new journey in life: a life of health and fitness. I trained hard and started IF (Intermittent Fasting). After an year of blundering along, I found my groove and results came in: resting heart rate down to 6o, blood glucose and lipid levels normal, and body fat well down (BW now 75 kgs). <a href="http://www.bmi-india.com/wp-content/uploads/2010/05/Picture-17.png"><img class="alignnone size-full wp-image-391" title="Picture 17" src="http://www.bmi-india.com/wp-content/uploads/2010/05/Picture-17.png" alt="" width="487" height="642" /></a></p>
<p>To come back to the point, the doctor I asked hit my problem with the drug hammer he was holding by default. I did the smart thing by trying something different. I now firmly believe that everyone should try healthy eating and exercise in order to improve health and reduce body fat. As bariatric surgeons, we should not use the surgery hammer to hit every obese patient. When there is clear burden of disease (diabetes, hypertension, sleep apnea, gallstone disease, etc.) and the level of obesity is such that it is statistically unlikely to come off with lifestyle regulation, we recommend bariatric surgery. Not otherwise.</p>
<p>In other words, as specialists dealing with obesity and related diseases, we should have a broad perspective. We are always in danger of using a narrow knife-wielder&#8217;s perspective and eyeing every patient as a potential victim. We must be very careful. At BMI, we never stop telling each other this.</p>
<p><strong><em>In clinical practice, the psyche of the patient is very important. But a more important factor (and an often unrecognized one) is the psyche of the doctor.</em></strong></p>

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		<title>ORLISTAT- A CANDIDATE FOR WITHDRAWAL?</title>
		<link>http://www.bmi-india.com/orlistat-a-candidate-for-withdrawal/</link>
		<comments>http://www.bmi-india.com/orlistat-a-candidate-for-withdrawal/#comments</comments>
		<pubDate>Tue, 25 Aug 2009 23:08:58 +0000</pubDate>
		<dc:creator>ramana</dc:creator>
				<category><![CDATA[Complications]]></category>
		<category><![CDATA[Diet]]></category>
		<category><![CDATA[Headline]]></category>
		<category><![CDATA[Obesity Research]]></category>
		<category><![CDATA[Practice]]></category>
		<category><![CDATA[blog]]></category>
		<category><![CDATA[fat loss]]></category>
		<category><![CDATA[nutrition]]></category>
		<category><![CDATA[bariatric surgery]]></category>
		<category><![CDATA[drugs for obesity]]></category>
		<category><![CDATA[fats]]></category>
		<category><![CDATA[obesity]]></category>

		<guid isPermaLink="false">http://www.bmi-india.com/?p=192</guid>
		<description><![CDATA[Many patients and physicians are averse to bariatric surgery for the management of morbid obesity and its attendant evils of diabetes, hypertension, sleep apnea, etc. Fair enough, I say, but then how do you achieve fat loss when you are unlikely to be in the 5% who will achieve it with lifestyle changes? Clearly, people [...]]]></description>
			<content:encoded><![CDATA[<p><span style="text-align:justify;"><br />
Many patients and physicians are averse to bariatric surgery for the management of morbid obesity and its attendant evils of diabetes, hypertension, sleep apnea, etc. Fair enough, I say, but then how do you achieve fat loss when you are unlikely to be in the 5% who will achieve it with lifestyle changes? Clearly, people who get morbidly obese are extremely hard pressed to get back into shape and health, even with medical supervision.</p>
<p><a href="http://www.bmi-india.com/wp-content/uploads/2009/08/alli.jpg"><img class="alignnone size-medium wp-image-194" title="alli" src="http://www.bmi-india.com/wp-content/uploads/2009/08/alli-300x245.jpg" alt="alli" width="300" height="245" /></a></p>
<p>In this scenario, they often resort to taking drugs to help with weight loss. One such drug, now popular all over the world, is <a href="http://en.wikipedia.org/wiki/Orlistat"><strong>Orlistat</strong></a>, sold over the counter in the US as Alli.<span id="more-192"></span></p>
<p>The drug works by inhibiting the digestion and absorption of ingested fat in the alimentary tract. Net result- the ingested fat is passed off in the stool. So, the patient can eat fats and not put it on&#8211; after all, it is not getting absorbed into the body. Cool, ain&#8217;t it?</p>
<p>Not really. The drug,<strong> </strong><a href="http://www.bmi-india.com/what-organs-control-our-body-fat/"><strong>as we have seen with rimonabant before</strong></a>, is not without its inherent problems. The stools become oily and loose, not to say foul-smelling. As a result of this, much time is spent in the toilet. If that is not bad enough, the oil trickles in through the anus and soils your clothes!</p>
<p>Orlistat (sold in India in the names of Reeshape or Obelit, among others) also causes malabsorption of fat-soluble vitamins and could be harmful if consumed for longer periods of time. Remember that fat is an important macronutrient for the body, even in fat people!</p>
<p>According to <a href="http://www.medpagetoday.com/ProductAlert/Prescriptions/15670?utm_source=twitter&amp;utm_medium=twitter&amp;utm_campaign=twitter"><strong>this report</strong></a><strong> </strong>(and some others), Orlistat has been found to cause severe liver toxicity, including liver failure in several patients, leading the FDA to launch a product review on the drug.</p>
<blockquote>
<p style="line-height: 15px;"><span style="color: #0000ff;"><em>FDA said it &#8220;is not advising healthcare professionals to change their prescribing practices with orlistat. Consumers currently taking Xenical should continue to take it as prescribed, and those using over-the-counter Alli should continue to use the product as directed.&#8221;</em></span></p>
<p style="line-height: 15px;"><span style="color: #0000ff;"><em>But the FDA advised orlistat users to &#8220;consult their healthcare professional if they are experiencing symptoms possibly associated with the use of orlistat and development of liver injury, particularly weakness or fatigue, fever, jaundice, or brown urine. Other symptoms may include abdominal pain, nausea, vomiting, light-colored stools, itching, or loss of appetite.&#8221;</em></span></p>
</blockquote>
<p>However, if history is any indicator, it is our prediction that this will go the way of rimonabant and Ephedra and die a natural death in some time in the future.<br />
</span></p>

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