BMI » india

A BMI PATIENT’S FEEDBACK

ramana — Tue, 06 Dec 2011 04:00:06 +0000

At BMI, we don’t generally talk about our successes. We focus, instead, on the science, the details that are not covered in counseling sessions with patients and their families. This is probably why we are on the first page of Google on most of the search terms for bariatric surgery.

Once in a while, we should (I think) take a break from this natural reluctance to brag. Not with the objective to actually brag, but with the aim of revealing what it feels from the other side: the patient’s side. Seriously. Take my word for it.

(yeah, the smiley is too big, but I can’t edit it to fit. Sue me!)

Enough said. Here is Sharon, from Ireland, who looks good enough to be a show-stopper and has actually done skydiving post-surgery:

It is now nine months since I have given birth to my new body. Well if its good enough at the start of life, its a good enough now because in many ways I have been reborn.

I travelled to India from Northern Ireland in January 2011. Little did I know the course my life would take during the nine months from entering the Bellvue Clinic that day. The gorgeous Saul made the wait in between assessments easy and he is a terrific ambassador for Drs Ramana and Baig. Surgery and post surgery care was incredible and if anyone from the UK National Health Service reads this – please take note because the NHS could learn a lot from these guys.

Back in Northern Ireland my life took on a new meaning. As the pounds dropped off my self confidence and esteem grew. It is a true saying – nothing tastes as good as slim feels. I was down several dress sizes before the summer and for the first time in over thirty years I bought a bikini for my holiday to Mauritius.

I was so happy to see the look of love my husband, Devendra had when he saw me wearing it because whilst in Mauritius he passed away. One of the hardest things I have ever had to do was to carry my darling husband’s ashes home to Northern Ireland. That was three months ago and I am coming to terms with losing Dev.

But what has all this got to do with bariatric surgery? EVERYTHING is the answer. As a butterfly must emerge from its chrysalis, so my inner strength was releashed. I am no longer the Sharon who hides her emotions under the kilos. The surgery and resultant weight loss has given me the liberation to expect the right to be respected for the woman I am. To misquote the line: ‘No one puts Sharon in the corner anymore’.

So far 2011has been an emotional rollercoaster ride, and its not over yet. In two weeks time, I shall be travelling to New Zealand to see my son Mark, who I have not seen since May 2009. As you can imagine, I can hardly contain my excitement at the thought of our reunion. As part of his itinerary for my trip, he has organised a tandem skydive for me. It would have been impossible for me to do this if I had been my weight at the beginning of the year and therefore will be a defining moment in this new chapter of my life.

What a fitting memorial to my wonderful husband.

Blondiexxxx

Click on pen to

REDUCING MORTALITY IN BARIATRIC SURGERY

ramana — Sun, 09 Oct 2011 13:52:52 +0000

As you may or may not know, mortality in bariatric surgery occurs at a very acceptable 0.2-0.3% rate. Compare this to gall bladder or appendix surgery (0.3 to 0.4%).

This means that in this class of obese people, if we operate on a thousand, two will die. If you take these same thousand people and just let them carry on the same way (with medical treatment, etc.) HALF of them would be dead in 20 years! In fact, the five year mortality of these patients is high enough to justify bariatric surgery.

Even though this is pretty impressive stuff to demonstrate how life-saving and life-altering bariatric surgery can be, what happens to an individual case where the patient dies? For that family, the mortality rate is 100%! Can things be any worse for them? No.

Therefore, if we could try and reduce the mortality of surgery even further, why would we not do it?

If we could weed out the highest risk cases, it would be half the battle won. We could then simply try not to operate on this high-risk class of patients, UNLESS there is a clear and explicit understanding and acceptance that they have a significant chance of dying within a month of surgery.

So the highest risk is seen in these groups:

Elderly
Males
High BMI
Smokers, alcoholics
History of pulmonary embolism/DVT
Re-do bariatric surgery

Recently, a paper showed statistics that suggest that bariatric surgery in elderly men does NOT offer the benefits other patients derive from it.

Why do patients die?

The most common reason is Pulmonary Embolism. Obese patients are prone to get blood clots in the leg and pelvic veins (Deep Vein Thrombosis) that can fragment and go into the blood stream before they get trapped in the lungs and obstruct the right heart’s main artery (pulmonary artery). To prevent this, we employ three common methods in hospital:

Chemical prophylaxis: injections of heparin or low molecular wight heparin (LMWH) daily under the skin till the patient is mobile and ambulant.
Mechanical prophylaxis: Sequential Compression Device (SCD) is used universally. The legs get compressed serially from below up by a machine that pumps air under pressure into stockings worn on the lower limbs.
Mobilisation: pre- and post-op movement out of bed is strongly encouraged. In special situations (paralysis, orthopedic handicap) the mobilisation may be done by a special physiotherapist.

Statistically, DVT/PE occurs even at home two weeks after the patient gets discharged. This clearly suggests that there is a chance of PE two weeks after stopping DVT prophylaxis. As this chance is maximal in the first month or so, it may be appropriate to continue LMWH injections for 30-45 days at home, especially when the patient falls into the high-risk category.

At BMI, we have now adopted this policy clearly for the higher risk patients.

In patients with a history of deep vein thrombosis or PE, further episodes of PE may be avoided by placing an umbrella in the IVC (the Inferior Vena Cava — the great vein carrying blood from the lower limbs and pelvis to the heart). This is done through a needle puncture in the groin.

Coronary heart disease is also a major cause of mortality. Obviously, the disease is pre-existing in these patients. Appropriate specialist care is needed, again obviously. It may be mentioned that almost all the risk factors for a heart attack are improved after bariatric surgery.

Among the surgical causes of death, leaks take the cake. Apart from that, intra-abdominal abscesses and bowel obstruction following gastric bypass or BPD/DS are important causes.

It has been said that most deaths following any surgery do not result from a single gigantic error, but rather from a series of small errors, each of which compounds and amplifies the complication leading to the patient’s demise. Suffice it to say that while the surgical complications mentioned above themselves are significant, they become lethal because of delayed diagnosis in two-thirds of cases. Negligence has been noted in nearly a third of such deaths.

Association of suicides with bariatric surgery has been a source of controversy, as we have discussed before.

As far as the surgical strategies to reduce mortality are concerned, we need to reduce leaks and obstructions and detect them early when they occur. Leak prevention includes using staple-line buttresses, suturing, avoiding too narrow a tube, and avoiding thermal injuries. Bowel obstruction prevention largely deals with closure of internal defects at the time of gastric bypass and avoiding the retrocolic approach.

References:

Causes of 30-day bariatric surgery mortality: with emphasis on bypass obstruction– Mason EE, Renquist KE, Huang YH, Jamal M, Samuel I.
The SOS Study: Sjöström
The Pennsylvania bariatric mortality study
Long-Term Mortality after Gastric Bypass Surgery: Ted D. Adams, et al.
Medicolegal analysis of 100 malpractice claims against bariatric surgeons: Cottam D, Lord J, Dallal RM, Wolfe B, Higa K, McCauley K, Schauer P.

Click on pen to

LEAKS AFTER GASTRIC BYPASS

ramana — Sun, 25 Sep 2011 23:06:00 +0000

Almost all people (with the exception of some bariatric surgeons) believe that the sleeve gastrectomy is a safer operation than the gastric bypass because of the ease and simplicity of the procedure, as also the possibility of leaks in the latter case (multiple staple lines). At the root of the confidence of many surgeons is the view that the stomach, being a vascular organ, would be a safe bet in healing.

This is an oversimplification, IMO.

I have mentioned before that the sleeve, in spite of being an easier and faster procedure, may be more problematic in terms of leak alone. The leak rate of the sleeve is around 2-3 percent, while that of the bypass is around the same, but the leaks behave differently.

The sleeve leak (as discussed in details before) is a high pressure leak, occurring usually at the angle of His, and tends to persist unless stented.

The bypass leak occurs at multiple possible sites, half in the gastrojejunostomy, but being a low pressure leak, tends to dry out on its own once the surgical re-exploration is done and issues sorted out.

(pic from referenced article)

Leaks after a bypass are usually detected on Day 3, give or take some. The detection may be because of routine dye study, but usually the patient already has a high pulse rate, fever, abdominal pain, dirty drain output, etc. It is important to remember that around a third of patients may have no clear evidence of a leak in spite of CT scan or dye test or both. In fact, in an older study, only a pulse rate over 120 and a rapid breathing rate were consistent in patients with leaks, and only 2 out of 9 leaks showed up on the dye study. This means that a laparoscopic re-exploration is the most reliable of investigations for a leak!

Upon detection of a leak after the bypass, the patients is usually re-explored laparoscopically. The procedure may include any or all of the following:

Re-suture of leak with omental graft
Re-do the full anastomosis
Partial remnant gastrectomy (in case of remnant staple line leak)
Drainage
Gastrostomy

While around 2 percent of bypasses may leak, when they do occur, they inflict considerable collateral damage: gastrogastric fistula, wound complications, lung problems, DVT/PE, etc.

It is also important to remember that a downstream problem like an obstruction of the jejunum may cause leaks from the staple line above.

Are there groups which have a predictably higher leak rate?

Yes, it may be said that the leak risks are higher in:

Revisional bariatric surgeries (around 13-14%)
Males.
Higher BMI.
Multiple co-morbidities.
Patients with previous abdominal operations.
Circular stapled anastomoses (hand-sewn method has the lowest leak rate of 0.4%): controversial!
Inexperienced surgical hands.
Those who have had an intraoperative mishap (colon/splenic injury, for example).
One leak may predispose to another.
Buttressed staple lines may have an advantage in leak rates.

The mortality of jejuno-jejunal leaks is close to 40-50 percent, while a GJ leak has a 10% mortality.

What happens once a leak is detected and the patient re-explored? Initial days may be stormy or tense, spent in the ITU with ventilatory support given to some patients (remember, many of these patients are already sick with other co-morbidities), and then the sepsis gets controlled and the nutrition support started (through the gastrostomy tube or through a central vein in the neck, etc.). The patient recovers slowly and the leak heals with time. In the rare case, if a leak persists beyond a month, a stent may be required.

With this post, our continuing exploration of the Achilles heel of all bariatric operations has been, you will admit, rather thorough. If this and the other articles frighten you, then be assured that this was and is not the goal of my writing. We at BMI believe that an informed patient is the best one, and we owe it to you to even out the information asymmetry in this highly technical branch of medical care. All surgeries have side effects, but they occur in a small minority of patients. In the given case, each complication hits hard, and a prepared patient handles it better. As bariatric surgeons, we need to brief you adequately as to the possible downsides of what is otherwise a transformational event in life.

Ref:

Diagnosis and Contemporary Management of Anastomotic Leaks after Gastric Bypass for Obesity

J Am Coll Surg

Rodrigo Gonzalez, MD, Michael G Sarr, MD, FACS, C Daniel Smith, MD, FACS, Mercedeh Baghai, MD, Michael Kendrick, MD, Samuel Szomstein, MD, FACS, Raul Rosenthal, MD, FACS, Michel M Murr, MD, FACS

Click on pen to

LEAKS AFTER SLEEVE GASTRECTOMY (PART THREE)

ramana — Thu, 22 Sep 2011 14:55:03 +0000

After the initial (and highly popular, if I may say so) posts on the subject (see Parts One and Two), we will now talk about what we have gained in terms of experience and insight about this subject.

I had jokingly noted how BMI has not had a leak in many years. This year (obviously our busiest year so far) we have had three leaks, each unique in mechanism, presentation and treatment.

I will discuss the cases separately later in my posts, and share some thoughts about this important topic.

Sleeve gastrectomy leaks behave totally differently compared to any other type. The reasons are multiple, and all lead to a persistent and nagging leak that may end up as a fistula (a tract between the stomach and the skin).

The causative factors are:

The pylorus (ring of muscle that acts a the gateway from the stomach into the duodenum) is normally closed, and the pressure in the gastric tube increases because of that, especially when a peristaltic wave builds up in the organ. The pressure may be as high as 45 mm Hg pressure, whereas the lower esophageal pressure is 20 mm Hg at most. The resultant gradient of pressure is from the pyloric end towards the esophagus. This leads to high pressure acting on the highest end of the staple line (near the GE junction). Greater the pressure, the higher the leak rate.
The GE junction area is least supplied by blood vessels. This would lead to relatively weaker healing.
The intrathoracic pressure is negative, and the pressure differential in the upper stomach, therefore, is high.
The gastric tube may twist in a corkscrew manner in the postoperative phase, perhaps as a result of the staple line running in different directions and the muscle layers getting transected at different levels.
The incisura of the stomach may be narrowed by the stapling. This would not only lead to high pressure build up in the stomach but also make leak management doubly difficult.

Whatever be the cause, leaks may increase mortality (10%), and certainly do increase hospitalisation and costs of treatment. In fact, in the Indian context, where insurance is nowhere in the picture, it is scary to imagine a leak in a patient with limited resources.

Some other points about sleeve leaks:

* The most leaks occur when both staple line buttresses and overrunning sutures are used (Gagner).

* Intersections of staple lines must always be oversewn to prevent leaks.

* The narrow sleeves leak the most compared to the wider ones (typically 32 Fr versus 40 Fr).

* Leaks may occur even as late as 2 to 4 weeks after operation, though this is not common.

* A leak mandates immediate re-exploration, drainage and insertion of a feeding tube (nasojejunal or jejunostomy or parenteral). Many experts now routinely insert a stent intraoperatively during the re-exploration. This possibly reduces hospital stay.

* A chronic leak persisting over three months is not amenable to endoscopic stenting and would need surgery.

Endoscopic stent management of sleeve leaks (some major points to bear in mind):

For stents to work, the defect should be less than 3 cm or less than 50% of the circumference of the organ.

As mentioned above, the consensus seems to be emerging that leaks should be stented during the re-exploration. At this re-exploration, an attempt may be made to identify the leak, suture it with an omental pedicle as buttress and drain the area. If the leak is not easily visible, one should not hunt it, for fear of causing injuries in the friable and inflamed area.

If a stricture is present along with a leak, two stents may be used to cover the entire sleeve, or the single stent has to reach up to the incisura/stricture.

SEMS for Sleeve Leak (video)

The stents used may be Self Expanding Plastic Stents (SEPS) known as Polyflex or SEMS (self expanding metal stents). The problem with the Polyflex or plastic stents is that they tend to migrate, while the SEMS stents are very difficult to remove. To this end, the two stents have different problems and different solutions have been tried successfully: to prevent migration of the SEPS stent, a thread is passed through the edge of the stent and brought out through the nose and tied to the patient’s ears (!). Ingenious and cheap. With the SEMS stent, double coating may make for easier removal. I have seen one presenter at IFSO 2011 at Hamburg mention and show esophageal avulsion injury during removal of a metal stent.

Stents cause problems:

Reflux
Salivation in the morning
Chest pain
Dislodgment
Erosion
Difficult removal

Stenting should be accompanied by endoscopic pyloric dilatation, using 20 psi pressure. This reduces the intra-sleeve pressure.

Checking the stent position every week or month (depending on the policy) is necessary.

Endoscopic methods other than stents:

For leaks less than 1 cm, several injections of fibrin sealant may lead to 100% success rates.
For the same kind of leak, argon laser coagulation has also been used (Basso).
Through-the-scope clips may be used for defects less than 1 cm.
Over-the-scope clips may be used for larger defects.
A Brazilian center advocates an endoscopic septotomy (division of a ridge like elevation that forms beside a chronic fistula) and cleaning up of the abscess adjoining the fistula, thereby leading to an internal drainage of the leak. This allows immediate removal of the drain. This is an unorthodox method of treatment.

Surgery:

For a chronic leak, surgery may be a last resort.

The simplest is to connect a jejunal loop to the fistula defect
The sleeve is converted to a gastric bypass and the fistula is left untouched. This converts the high pressure sleeve leak to a low pressure bypass leak. The fistula then dries out.
Conversion to bypass and stoma constructed at the leak site.
Total gastrectomy with esophagojejunostomy (Neto).

I hope this series has been educational for you, whether you are a patient, relative, doctor or student.

Click on pen to

MAKING THE MOST OUT OF LIFE AFTER BARIATRIC SURGERY

ramana — Sun, 08 May 2011 13:26:34 +0000

Those who undergo or contemplate bariatric surgery do so essentially as a second chance at life. I mean that the severely obese man or woman feels that he (or she) has lost out in life on multiple fronts. Here are a few examples:
Loss of body contour/beauty: you can’t forget how you were once before the fat started piling on.
Poor self image: you hate the thing you see in the mirror.
Poor quality of life: you can’t dance, surf, skip, run or walk without some kind of pain or discomfort. Going up one floor makes you breathless. You avoid holidays where you would need to walk, especially on hilly terrain.
Sexual issues: whether it is inability or unwillingness of one’s partner, sex life may take a back seat or even come unseated!
Health loss: you suddenly have been diagnosed to be having diabetes or heart disease (or anything else) and, suddenly, life sucks!
Social alienation: Even though there have never been as many obese people in the planet as the present, the morbidly obese individual catches everyone’s eye the wrong way. People make jokes, there is job discrimination, and even marriages get burnt!
The need for bariatric surgery serves as the wake-up call. What many people don’t realise is that bariatric surgery should not (and is not) a short cut. You cannot eat all you want and stay slim after the surgery. Therefore, if you look at the long term figures of weight loss after bariatric surgery, it may be as low as 40 to 50 percent, though the initial weight loss achieved may be 75%.
Obviously, we know weight regain is an issue for patients, and has to be addressed properly.
Even better is if you can program your life to prevent weight regain.
An unnamed BMI patient (we take our patients’ privacy seriously) writes to me:

Seems like such a long time ago that I was through surgery. I am still learning what I can and cannot do regarding food. I have a different attitude towards food now, which I never would have believed possible. I find the Paleo Diet hard to follow but have taken some of it on board and restrict foods, such as bread and potatoes to a bare minimum (a couple of slices of bread per week) and I haven’t eaten rice since surgery. I eat an egg for breakfast and sometimes mushrooms. The days of a full Ulster fry-up are long since gone, and dinner is served on a small side plate. I see the portions people eat and shudder. I have seen me ask for a children’s portion and still not finish it. I still have some milk in coffee and I eat natural yoghurt, which is not permitted but in general, my eating habits have really improved. Fresh fruit and veg, and some fish or chicken. I can only digest minced red meat and even then, only in small quantities, but nothing can equal how I feel.

(Eat This!)

(And This!)

As I keep saying, eat natural foods and avoid man-made food products.

(Stay strong when life tempts you!)

She reflects the pursuit of that kind of eating style (like primitive or Paleo man) that I teach. In addition, she has taken up kettlebell training and getting active in general. What does a lifestyle like this (without chips, pizza, cakes and bread on a daily basis) feel to the mind?

I can’t really explain the change which has occurred inside. I have my positive attitude back and feel I can tackle the challenges with more confidence than I have had in ages. The fact I am free of all medication is also a tremendous bonus.

And the bonuses keep coming to keep you motivated.

I saw my cousin today and she couldn’t believe how well I looked since the last time she saw me. I didn’t tell about the surgery, reasoning it was my business and she didn’t need to know. She congratulated me but then admonished me not to put it back on again. I assured her that wasn’t going to happen and left it at that.
I’m enjoying being normal and, for the time being, I am happy about that. I remember you saying that was a very low priority but for the moment, I am content. I now weigh what I did in 1995 and most people have never seen me this size so it comes as a bit of surprise.

Thank you, my dear (you know who you are): these words have inspirational content that mere doctors can only hope to provide!

All photos are original property of BMI.

Click on pen to

GASTRIC BYPASS: CHOOSING THE STOMA

ramana — Thu, 21 Apr 2011 00:00:49 +0000

Weight loss after the lap gastric bypass is a well known fact. What is less known is that there is a certain degree of weight regain in some patients in the long term.

Before we proceed, do you know what is a lap gastric bypass all about?

An important factor to be considered by every patient/doctor involved in a gastric bypass is how the stoma for the pouch would be created, as it is one of the known factors leading to weight regain.

The stoma is the opening we create between the gastric micro-pouch and the upper small bowel (jejunum). Too big a stoma will lead to food exiting the pouch quicker and resultant weight regain. Too small a stoma would lead to obstructive symptoms and misery.

So what is the ideal stoma size: 12 mm, 14 mm, 18 mm, or 25 mm? And how would we create this stoma? Does the stoma size stay that way all life at the same size?

Easy, tiger, easy. One thing at a time!

Ideal stoma size:
Different people seem to be using different sizes. A popular way of creating the stoma is with the EEA circular stapler and the OrVil device. The stoma created is either 21mm or 25mm in size.
The stoma is a little big but it is known to contract in size later. The risk of stenosis being highest in the circular stapler group, it is perhaps better to keep stoma size around this level. A smaller stoma may stenose and cause obstructive symptoms. The incidence of stenosis is less than 3 percent.

The hand-sutured technique (my personal favorite) is known to stenose the least in the long term. Here the stoma size is 12 mm/36 Fr. In case you are wondering how we can measure in millimeters in lap surgery, we pass a 36 Fr gastric tube through the mouth into the pouch. The anastomosis between the pouch and the jejunum is fashioned over this tube.
A stoma can be created with the Linear Stapler. This leaves the anterior (front) walls open, and need hand-suturing to complete the process. The stoma also tends to be excessively wide, in my experience. Therefore, at BMI, we don’t favor this method, preferring the hand-sewn and EEA techniques instead.
So the keen patient here would be wondering, “Which is better or best?”
Like most things in life, it depends. Each method of stoma creation has its pros and cons.
The EEA circular stapled method is quick and mechanised, so suturing is not a major issue. The stoma is reliably and safely created, with minimal leak rates. However, it is expensive, needs the surgeon to be familiar with the device, and has the highest stenosis rates. On top of that, technical disasters are not unknown (study in colorectal context).

The hand-sewn method (best demonstrated by Kelvin Higa) is also safe, reliable and avoids mechanical stapler failures and disasters. It needs the highest level of skills in the surgeon, and is more time consuming in most hands. Experts, however, can complete this quickly.

The Linear Stapler method is easy for most surgeons, but has very little to recommend it.

One final issue with the stoma: do we need stoma to be buttressed, or glued? It may by nice to do and for us to see in the operating room, but it probably does not reduce leak rates significantly. In the high-risk patient we may choose to use it. Some studies do report significant benefits in reduction of bleeding, leaks and stenoses.

The bottomline is to ask your surgeon how he would create the stoma, and what he prefers. Then make up your mind to go for it. You have more to gain by that decision: that one thing that will transform your life.

Click on pen to

DOES BOUGIE SIZE IN SLEEVE GASTRECTOMY MATTER?

ramana — Mon, 07 Feb 2011 22:57:50 +0000

When we started out on doing the sleeve gastrectomy a few years back, it was typically over a 60Fr bougie. The important thing, we learnt, was not to leave any part of the fundus of the stomach behind. This was the important technical thing to check. Our old patients have all done well.

Since the last couple of years, however, it has become commonplace to do tight sleeves over bougies 32-36 Fr. The idea is that a tighter sleeve is more restrictive in terms of stomach capacity and would give faster and better weight loss.

This article examines the truth.

Gagner et al had published an article in Obesity Surgery in 2008 showing better safety profile in their own series for patients who had 60 Fr sleeves compared to those who had narrower 40 Fr sleeves. Today, however, we are talking of much tighter sleeves. The question, therefore, could be “Does a sleeve twice as tight as a conventional 60 Fr sleeve give better results?”

Recent studies have shown that tight sleeves have shown good results. In fact, many of us in India have no regrets doing tight sleeves, with equivalent weight loss in the short term and 85-100% resolution of diabetes mellitus.

At BMI, we use around 34 Fr or 38 Fr, but end up with a slightly tighter sleeve because of meticulous oversewing of the staple line.

The most important consideration in designing a tight sleeve is to ensure that there is no narrowing at the level of the incisura (the sag-point of the stomach where the organ turns horizontally towards the right of the patient). A narrowing will cause a leak at the GE junction or lead to persistent vomiting later, necessitating invasive treatment later. All in all, a highly regrettable outcome could ensue, so it is wise to leave a wider incisura than make it too tight.

Some new thoughts are also currently being aired on improving outcomes after the sleeve. Could the gastric tube, detached from its greater curve attachment of gastrocolic (“greater”) omentum, get coiled up later and impair emptying of the organ? Would it be wise to re-anchor the omentum to the stomach tube?

We really don’t know yet. Interesting possibilities abound, but the truth is by no means established.

In recent times, several studies have reported no increase in complications when the staple line is not reinforced with stitches. In fact the last one I read talked of zero leaks in more than 500 cases. At BMI, we have now switched from ”meticulous suturing of the staple-line” above to stitches placed at the junction of adjacent staple lines.

And, so far, we are free from the disaster of leaks (knocks on wood).

So, if we create tighter sleeves with a narrow bougie (between 32 and 36 Fr) would we have a higher rate of strictures? No. In a recent article in a journal, Zundel et al have reported a 0.26 % stricture rate. The cause of stricture may be:

1. A hematoma (blood clot) causing compression

2. Stitch causing narrowing

3. Ischemia due to inadvertent vascular injury to branches of the left gastric artery.

4. Kinking of the gastric sleeve (due to stitches, stapling technical errors, etc). This can occur regardless of sleeve size.

5. Fistula: the associated inflammation causes narrowing.

6. Band removal cases, usually associated with much fibrosis.

7. Mucosal edema and food impaction can also cause acute blockage.

References:

1. Gagner M, Deitel M, Kalberer TL, et al. The Second International Consensus Summit for Sleeve Gastrectomy, March 19-21, 2009. Surg Obes Relat Dis. 2009;5:476–485.

2. Frezza EE, Reddy S, Gee LL, et al. Complications after sleeve gastrectomy for morbid obesity. Obes Surg. 19:684–687.

3. Lalor PF, Tucker ON, Szomstein S, et al. Complications after laparoscopic sleeve gastrectomy. Surg Obes Relat Dis. 2008;4: 33–38.

4. Zundel, et al. Strictures After Sleeve Gastrectomy.

Surg Laparosc Endosc Percutan Tec, Volume 20, Number 3, June 2010

5. DE Bellanger, FL Greenway. Laparoscopic Sleeve Gastrectomy: 529 cases without a leak.

Click on pen to

IS DIABETES CURABLE BY SURGERY?

ramana — Sun, 06 Feb 2011 10:11:13 +0000

Note: This article discusses only Type II Diabetes Mellitus

It has always been a given for generations that ‘once a diabetic, always a diabetic’. Absolutely like the truism for high blood pressure, asthma and hypothyroidism. You know that if you are unlucky enough to get these labels stuck on you, you are going to take pills or injections all your life and suffer the disease as it progresses into making each organ weaker than ever before. No more.

Riya, a plump 50-year-old diabetic who was taking insulin injections for many years, was fed up of her lifestyle and the fact that she was developing complications of diabetes and high blood pressure. Being highly educated, she searched the Internet for newer options. Every website she visited mentioned high cure rates after gastric bypass surgery. She came to us at Belle Vue Clinic, where we did the same surgery on her (keyhole method). Riya’s blood sugar, always in the high 300s, normalized immediately after her surgery. Discharged after a couple of days, she joined back her school in a week, no longer worried about her blood sugar. Her colleagues are now asking her about her secret – how did her weight and blood sugar get under control so quickly?

In 1994, an American doctor called Walter Pories published a scientific paper provocatively titled, “Who would have thought it? An operation is the cure for Type II Diabetes Mellitus!” This paper showed the astonishing results that an operation called gastric bypass led to patients getting cured of diabetes in nearly 90 percent of cases. Blood sugar levels stay normal even several years after the operation.

Since then, this kind of operation, called ‘Metabolic Surgery’ or ‘Bariatric Surgery’ has become a standard across the globe.

What is done in the gastric Bypass?

We staple the stomach to form a very small pouch. When swallowed food comes from the food-pipe into this pouch, it meets a dead end. So we need to create a way for the food to go down. To do this, we take the small intestine up and create a channel between it and the stomach pouch. So, now the food goes into the small gut, bypassing most of the stomach and upper small bowel.

How Does This Work?

This works by reducing the stomach’s capacity to take in food, leading to satiety upon consuming a small portion of around an ounce of fluid. There is reduced spike in blood glucose after food (less volume + less absorption= low nutrient absorption).

The net effect of this operation is that undigested food reaches the small bowel, leading to the release of some hormones called incretins. These incretins (a group of around 200 chemicals) act to bring down the blood sugar levels and also halt the deterioration of pancreatic hormonal function that is the hallmark of Type II Diabetes Mellitus.

It is now clear that the alarming rise in cases of diabetes is linked to the widespread obesity in towns and cities. Indeed, 80 percent of new diabetics are fat to varying degrees. So far, doctors have been advising diabetics to lose weight by diet control and exercise, and to take medicines for diabetes. To a large extent, this is a hit-and-miss method of treatment, as there is no sure and predictable response in patients, largely because everyone differs in how strictly they follow their dietary discipline. Most people cheat on their diet, don’t exercise beyond the irregular morning walks and keep getting new complications of diabetes every year.

Most of these patients who undergo the gastric bypass procedure are also very obese. Says Dr. Arindam Ghosh, a bariatric surgeon based in Ludhiana’s Apollo Hospital, “Many of my diabetic patients are obese Punjabis weighing up to 200 kgs. Some of them live in the US and Canada, where the obesity levels are far greater than in India.”

Even though increasing numbers of our patients are searching the Internet daily for information, awareness levels are still abysmal. Patients think surgery involves physical removal of fat from their body. The younger generation is taking the lead. Yogesh Sharma, a 19 year old student who weighed 168 kgs, came to me for surgery to reduce his weight and cure his diabetes after convincing his parents that his decision was the correct one. To their credit, the Sharmas saw merit in the scientific approach. Most people are, however, very scared of the very word ‘surgery’ and would rather see their lives slowly but surely getting spoiled by disease.

Many people like Ruchita Doshi, a 57-year-old lady who has undergone spine surgery, regret their decision, “I wish I had undergone bariatric surgery before. My obesity led to arthritis and spine disease for which I needed to spend rupees three lakhs on treatment. Now they say I cannot be operated as I am undergoing dialysis because of diabetic nephropathy (end stage kidney disease).” Ruchita shares the opinion of many doctors that surgery for diabetes cure would have offset the costs of the complications of the primary disease. What are you doing about your obesity and diabetes?

Click on pen to

THE OBESITY PILL-A MYTH?

ramana — Wed, 27 Oct 2010 13:59:41 +0000

I, like many others, have long believed that science will, one day, announce the discovery of a pill that will end obesity. One pill, and pow! no more cravings, and fat will melt off your muscles like wax from a lit candle.

(pic: bmj.com)

Many companies have clearly shared that fantasy or vision. Billions of dollars are at stake to be the one to discover the ultimate pill. The Ultimate Pill™ will have the following characteristics:

1. Help burn fat

2. Allow you to eat normally without putting on fat

3. Have no side effects

4. Be cheap and easily available

5. Reverse obesity-related changes (this is perhaps taking things too far)

Obviously, we are nearly talking science fiction here.

The various drugs that have been used in the past are now mere footnotes in the history of obesity medicine. Heard of fenfluramine? A few years back, rimonabant was said to be the wonder drug, working through some mysterious cannabinoid receptors in the brain (how exotic it sounds!). That fell through, because people were getting depressed enough to commit suicide.

Sibutramine and Orlistat have been heavily prescribed by physicians around the world to effect weight loss short of bariatric surgery. Sibutramine causes appetite suppression, while orlistat affects fat absorption and allows unhealthy eating without the fear of weight gain. So they said.

We have said it before that orlistat can cause liver problems, and is a candidate for withdrawal. Now the world is told that sibutramine has been withdrawn in the US, Canada and Europe because of heart attacks (the SCOUT study).

The BMJ says:

The therapeutic cupboard containing antiobesity drugs has never been well stocked. The European Medicines Agency (EMA) recently decided that sibutramine must follow the example of rimonabant, withdrawn last year because of safety concerns. This leaves just one drug—orlistat—to face the rising tide of obesity across the continent. The demise of sibutramine carries both irony and wider messages for the management of obesity.

Sibutramine fell at the crucial hurdle of cardiovascular risk. Arterial disease—which leads ultimately to myocardial ischaemia, heart failure, and stroke—affects most obese people to some degree and is their major cause of death. Much evidence suggests that weight loss decreases morbidity and mortality associated with cardiovascular disease,3 and this is an important justification for all antiobesity measures, including drugs. Unfortunately for sibutramine, an interim analysis of the SCOUT (Sibutramine Cardiovascular Outcome Trial) study found that the drug increased morbidity from cardiovascular disease. The odds were always stacked against sibutramine, because cardiovascular risk is embedded in its mechanism of action. Sibutramine acts centrally to reduce food intake; it inhibits the presynaptic reuptake and degradation of serotonin and noradrenaline, thus enhancing the appetite suppressing actions of both neurotransmitters.

Why drugs have not yet worked for weight loss in obese patients may be due to the fact that obesity is a heterogeneous disease with multiple factors, whereas the drug tends to be focal in its mechanism of action.

So, sadly, another drug has failed. The role of bariatric surgery is as crucial as ever. It is now the only scientifically proven method of weight loss. What is more, it is safe and effective. As study after study keeps showing us. But will the naysayers hear the truth?

Click on pen to

GASTRIC PLICATION: A NEW WLS PROCEDURE!

ramana — Sun, 18 Jul 2010 04:22:12 +0000

Many bariatric surgeons are excited about the procedure Gastric Plication (LGP) as a bariatric procedure. It promises to be a simple method (remember, “Less Is More!”) that gives weight loss results as good as sleeve gastrectomy without even the risks of that procedure (staple line leaks (read part one and part two here) or bleeding).

What is done is that the greater curvature of the stomach is freed from the tissues attached to it (known as the gastrocolic omentum) using a vessel sealing device like the Harmonic Scalpel or the Ligasure. This is the first step of the sleeve gastrectomy procedure, as well.

However, unlike the sleeve, here we do not use the stapler to remove 80% of the stomach. We merely imbricate/plicate the stomach using running stitches from above downwards, layer by layer, till most of the stomach is pushed inwards, creating a narrowing of the passage, and a tunnel along the lesser curvature, just like the sleeve.

Lap Gastric Plication

In the same vein, if someone wants to reverse the procedure, the stitches may be removed by laparoscopy (making this a potentially reversible procedure like the Lap Band), though this would neither be a good thing nor a great experience!

Some patients have significant reflux symptoms after LGP, as after the sleeve, as we have discussed before.

It is possible that the stitches may give way later and hamper the weight loss, but preliminary results, as presented in the recent International Conference of Obesity in Stockholm, show good results akin to the sleeve.

More info later!

Click on pen to